serum antibiotic concentrations can occur in such individuals following usual doses.
Cefpodoxime, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics.
As with other antibiotics, prolonged use of cefpodoximeproxetilmay result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient’s condition is essential. If superinfection occurs during therapy, appropriate measures should be taken.

Drug Interactions
Antacids:Concomitant administration of high doses of antacids (sodium bicarbonate and aluminum hydroxide) or H2 blockers reduces peak plasma levels by 24% to 42% and the extent of absorption by 27% to 32%, respectively.
Oral anti-cholinergics: (e.g., propantheline) delay peak plasma levels (47% increase in Tmax), but do not affect the extent of absorption (AUC).
Nephrotoxic drugs: Although nephrotoxicity has not been noted when cefpodoximeproxetilwas given alone, close monitoring of renal function is advised when cefpodoximeproxetilis administered concomitantly with compounds of known nephrotoxic potential.

Dosage and administrationType Of Infection Total Daily Dose Dose Frequency Duration
Acute Otitis Media 10 mg/ kg / day
(Max.400 mg/day) 5 mg/kg Q 12 h
(Max. 200 mg/dose) 5 days
Pharyngitis and/or tonsillitis 10 mg/ kg/ day
(Max 200 mg/day) 5 mg/kg/doseQ 12 h
(Max 200 mg/day) 5-10 days
Acute Maxillary Sinusitis 10 mg/kg/day
(Max 400 mg/day) 5 mg/kgQ 12 h
(Max 200 mg/dose) 10 Days

Lower respiratory tract infection 10 mg/Kg/day
(Max 400 mg/day) 5 mg/Kg Q 12 h
(Max 200 mg/dose) 10 to 14 days
Urinary tract infection 10 mg/Kg/day
(Max 400 mg/day) 5 mg/Kg Q 12 h
(Max 200 mg/dose) 7 to 14 days