Description
Each Tablet contain :
50 mg Sitagliptin/1000 mg metformin HCl
- Sitagliform is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes
mellitus
Take Sitagliform orally twice daily with meals.
- Sitagliform is contraindicated in patients with:
• Severe renal impairment.
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• History of a serious hypersensitivity reaction to Sitagliptin/metformin HCI, sitagliptin, or metformin, such as
anaphylaxis or angioedema.
A box containing 30 film coated tablets.
In patients with type 2 diabetes mellitus, administration of sitagliptin led to inhibition of DPP-4 enzyme activity for
a 24-hour period. After an oral glucose load or a meal, this DPP-4 inhibition resulted in a 2- to 3-fold increase in
circulating levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased responsiveness
of insulin release to glucose, resulting in higher C-peptide and insulin concentrations. The rise in insulin with the
decrease in glucagon was associated with lower fasting glucose concentrations and reduced glucose excursion
following an oral glucose load or a meal.
In studies with healthy subjects, sitagliptin did not lower blood glucose or cause hypoglycemia.
Sitagliptin and Metformin Coadministration
In a two-day study in healthy subjects, sitagliptin alone increased active GLP-1 concentrations, whereas
metformin alone increased active and total GLP-1 concentrations to similar extents. Coadministration of
sitagliptin and metformin had an additive effect on active GLP-1 concentrations. Sitagliptin, but not metformin,
increased active GIP concentrations. It is unclear what these findings mean for changes in glycemic control in
patients with type 2 diabetes mellitus.
